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KMID : 0616619970030010123
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Journal of Soonchunhyang Medical College
1997 Volume.3 No. 1 p.123 ~ p.136
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An Immunohistochemical Study for p53, EGFR and PCNA Expression in Gastric Adenocarcinoma
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Abstract
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Expression of oncogene in the gastric adenocarcinoma was considered as a determinant factor of cancer progression or prognosis by some authors, however, the results were so fluctuated according to the authors that there was no uniform agreement in their clinicopathological correlation as well as in its practical application. To evaluate correlation between the pathologic finding and the expression of p53, EGFR and PCNA, immunohistochemical studies were performed on paraffin-embedded sections of 84 gastric adenocarcinomas.
Pathologic findings were classified as 4 subgroups by their histologic types, differentiation, invasion and lymph node metastasis. The correlation of PCNA labelling index with various clinicopathologic factors and oncogene expression was studied.
The results were as follows;
1. p53 expression was seen in 47cases(55.56%) of gastric carcinoma, and correlation between p53 expression with tumor type, differentiation, invasion and lymph node metastasis was not proved. EGFR positive expression was found in 37(44.05%) cases and was increased in advanced gastric carcinoma, and cases of lymph node metastasis.
2. Co-expression of p53 and EGFR was observed in 18 cases(33.33%), suggesting existence of both oncogene in the same case, while both negative cases were 18 cases(33.33%) that suggest the possibility of presence of the other factors.
3. PCNA labelling index was higher in advanced gastric carcinoma and in cases of lymph node metastasis, but there was no statistical significance.
4. There was no statistical significance between PCNALI and p53 expression.
5. PCNALI and EGFR expression was parallel with pathologic finding such as differentiation, progression and metastasis of the carcinoma, these results suggest that there was significant correlation between PCNALI and EGFR.
6. PCNALI was statistically significant between two groups of both p53 and EGFR positive and both negative.
7. PCNALI showed statistical significance between EGFR positive and negative groups in cases of lymph node metastasis.
In summary, the value of p53 expression as a prognostic factor was still doubtful but EGFR and PCNA expression tended to be associated with tumor progression and seemed to be objective and reliable prognostic factors, respectively. Combined method of EGFR and PCNA thought to be more helpful in preoperative decision or prediction of prognosis in gastric carcinoma.
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KEYWORD
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